Table 2 Risk of OSCC by family history of cancer and head and neck cancer in first- and second-degree relatives after exact matching of cases and controls
From: The role of family history of Cancer in Oral Cavity Cancer
Cases n = 255 | Controls n = 255 | p-value | OR | 95% CI | |
|---|---|---|---|---|---|
Family history of cancera | |||||
Overall family | |||||
Negative | 127 (49.8) | 130 (51.0) | 0.48 | 0.95 | 0.82–1.1 |
Positive | 128 (50.2) | 125 (49.0) | |||
1 | 72 (28,2) | 67 (26.3) | |||
2 | 31 (12.2) | 32 (12.5) | |||
3 | 22 (8.6) | 14 (5.5) | |||
> 3 | 3 (1.2) | 12 (4.9) | |||
Parents | |||||
Negative | 182 (71.7) | 161 (63.4) | < 0.05 | 0.73 | 0.55–0.98 |
Positive | 72 (28.3) | 90 (36.6) | |||
One parent | 58 (22.8) | 72 (28.3) | |||
Both parents | 14 (5.5) | 18 (8.3) | |||
Siblings | |||||
Negative | 203 (79.9) | 221 (87.0) | < 0.01 | 1.59 | 1.17–2.89 |
Positive | 51 (20.1) | 33 (13.0) | |||
1 | 35 (13,8) | 29 (11.4) | |||
2 | 15 (5.9) | 4 (1.6) | |||
3 | 1 (0.4) | 0 | |||
Children | |||||
Negative | 248 (97.2) | 250 (98.4) | 0.52 | 1.50 | 0.42–5.31 |
Positive | 7 (2.8) | 5 (1.6) | |||
Second degree | |||||
Negative | 228 (89.8) | 227 (89.4) | 0.30 | 0.87 | 0.67–1.13 |
Positive | 26 (10.2) | 27 (10.6) | |||
1 | 16 (6.3) | 15 (5.9) | |||
2 | 8 (3.1) | 5 (2.0) | |||
> 2 | 2 (0.8) | 7 (2.8) | |||
Grandparents | |||||
Negative | 244 (96.1) | 237 (93.3) | 0.06 | 0.53 | 0.27–1.03 |
Positive | 10 (3.9) | 17 (6.7) | |||
1 | 10 (3.9) | 11 (4.3) | |||
2 | 0 | 4 (1.6) | |||
3 | 0 | 2 (0.8) | |||
Family history of head and neck cancera | |||||
Negative | 240 (94.3) | 244 (96.6) | 0.75 | 1.11 | 0.59–2.07 |
Positive | 15 (5.7) | 11 (3.4) | |||
1 | 14 (5.3) | 10 (3.0) | |||
> 1 | 1 (0.4) | 1 (0.4) | |||