Frequency of osteoradionecrosis of the lower jaw after radiotherapy of oral cancer patients correlated with dosimetric parameters and other risk factors

Table 2 Univariable and multivariate analysis of risk factors for ORN

	HR	95% CI	p-value
Univariate analysis
Gender (male vs. female)	1.837	0.847–2.984	0.124
Age	1.002	0.974–1.031	0.886
T-stage	1.320	0.962–1.813	0.086
Poor dental status (caries, periodontal disease)	1.618	0.740–3.537	0.228
Pre-RT dental treatment	4.822	2.055–11.316	0.001
Smoking history	1.279	0.672–2.435	0.453
D_mean to mandible	1.950	1.770–2.170	0.043
D_max to mandible	1.492	1.257–2.943	0.033
Concomitant systemic therapy	1.163	0.769–1.759	0.475
PTV dimension	1.001	1.000–1.003	0.028
Multivariate analysis
Pre-RT dental treatment	4.567	1.817–11.477	0.001
D_mean to mandible	2.421	1.023–5.728	0.044
D_max to mandible	1.334	1.135–2.827	0.018
PTV dimension	1.001	1.000–1.003	0.046

ISSN: 1746-160X