Fig. 4

Identification of critical states for tumor deterioration in NPC. (A) The index of critical transition (Ic.shrink score) of different recurrent patterns. The Ic.shrink scores for the identified dominant group (red curve) and random verification groups from bootstrap (blue curves). (B) Enriched GO pathways of biological process for identified 15 critical transition signals in ER status. ER, early recurrence; GO, Gene Oncology; LR, late recurrence; NPC, nasopharyngeal carcinoma; NR, non-recurrence